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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
2000 4
2001 4
2002 17
2003 22
2004 27
2005 13
2007 5
2008 7
2009 7
2010 7
2011 4
2012 15
2013 11
2014 10
2015 10
2016 13
2017 23
2018 13
2019 10
2020 10
2021 16
2022 5
2023 13
2024 8

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245 results

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Page 1
Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1-Foxo1 and PI3K-Akt signalling pathways.
Ren BC, Zhang YF, Liu SS, Cheng XJ, Yang X, Cui XG, Zhao XR, Zhao H, Hao MF, Li MD, Tie YY, Qu L, Li XY. Ren BC, et al. J Cell Mol Med. 2020 Nov;24(21):12355-12367. doi: 10.1111/jcmm.15725. Epub 2020 Sep 22. J Cell Mol Med. 2020. PMID: 32961025 Free PMC article.
Streptozoticin -induced diabetic rats showed metabolism abnormalities and elevated markers of OS (superoxide dismutase [SOD], malondialdehyde [MDA], gp91(phox) , Cyt-Cyto C), enhanced cell apoptosis (Bax/Bcl-2, Cleaved caspase-3, TUNEL-positive cells), together with reduced Akt p …
Streptozoticin -induced diabetic rats showed metabolism abnormalities and elevated markers of OS (superoxide dismutase [SOD], malondialdehyd …
Deletion of skeletal muscle Akt1/2 causes osteosarcopenia and reduces lifespan in mice.
Sasako T, Umehara T, Soeda K, Kaneko K, Suzuki M, Kobayashi N, Okazaki Y, Tamura-Nakano M, Chiba T, Accili D, Kahn CR, Noda T, Asahara H, Yamauchi T, Kadowaki T, Ueki K. Sasako T, et al. Nat Commun. 2022 Oct 5;13(1):5655. doi: 10.1038/s41467-022-33008-2. Nat Commun. 2022. PMID: 36198696 Free PMC article.
Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve as a model of premature sarcopenia with insulin resistance. ...These phenotypes are almost reversed by additional knocking out of Foxo1 …
Here we show that mice with skeletal muscle-specific double knockout of Akt1/2, key downstream molecules of insulin signaling, serve …
Chinese herbal medicine alleviates autophagy and apoptosis in ovarian granulosa cells induced by testosterone through PI3K/AKT1/FOXO1 pathway.
Hu W, Xie N, Pan M, Zhang Q, Zhang H, Wang F, Qu F. Hu W, et al. J Ethnopharmacol. 2024 Jan 10;318(Pt B):117025. doi: 10.1016/j.jep.2023.117025. Epub 2023 Aug 9. J Ethnopharmacol. 2024. PMID: 37567425
Additionally, the inhibition of autophagy diminished apoptosis, while the repression apoptosis enhanced autophagy. Finally, BSJPF significantly decreased the FOXO1 expression levels induced by testosterone, especially for nuclear FOXO1, and significantly activated t …
Additionally, the inhibition of autophagy diminished apoptosis, while the repression apoptosis enhanced autophagy. Finally, BSJPF significan …
Glycophagy mediated glucose-induced changes of hepatic glycogen metabolism via OGT1-AKT1-FOXO1(Ser238) pathway.
Wu LX, Xu YC, Pantopoulos K, Tan XY, Wei XL, Zheng H, Luo Z. Wu LX, et al. J Nutr Biochem. 2023 Jul;117:109337. doi: 10.1016/j.jnutbio.2023.109337. Epub 2023 Mar 28. J Nutr Biochem. 2023. PMID: 36990368
The glucose-dependent O-GlcNAcylation of AKT1 by O-GlcNAc transferase (OGT1) enhances the stability of AKT1 protein and promotes its binding with FOXO1. Moreover, the glycosylation of AKT1 is crucial for promoting FOXO1 nuclear translocation and …
The glucose-dependent O-GlcNAcylation of AKT1 by O-GlcNAc transferase (OGT1) enhances the stability of AKT1 protein and promot …
Identification of XAF1 as an endogenous AKT inhibitor.
Chen M, Wang K, Han Y, Yan S, Yuan H, Liu Q, Li L, Li N, Zhu H, Lu D, Wang K, Liu F, Luo D, Zhang Y, Jiang J, Li D, Zhang L, Ji H, Zhou H, Chen Y, Qin J, Gao D. Chen M, et al. Cell Rep. 2023 Jul 25;42(7):112690. doi: 10.1016/j.celrep.2023.112690. Epub 2023 Jun 27. Cell Rep. 2023. PMID: 37384528 Free article.
Herein, we identify XAF1 (XIAP-associated factor) as a direct interacting protein of AKT1, which strongly binds the N-terminal region of AKT1 to block its K63-linked poly-ubiquitination and subsequent activation. ...And ectopic expression of wild-type XAF1, but not …
Herein, we identify XAF1 (XIAP-associated factor) as a direct interacting protein of AKT1, which strongly binds the N-terminal region …
Kaixin Jieyu Granule attenuates neuroinflammation-induced depressive-like behavior through TLR4/PI3K/AKT/FOXO1 pathway: a study of network pharmacology and experimental validation.
Xu M, Zhai W, Zhang Y, Pan J, Li J, Huang S. Xu M, et al. BMC Complement Med Ther. 2023 May 12;23(1):156. doi: 10.1186/s12906-023-03970-5. BMC Complement Med Ther. 2023. PMID: 37173696 Free PMC article.
RESULTS: Our network-based approaches indicated that ginsenoside Rg1 (GRg1) and saikosaponin d (Ssd) are the major constituents of KJG that exert an anti-depressant effect by regulating TLR4, PI3K, AKT1, and FOXO1 targets through the toll-like receptor, PI3K/AKT, an …
RESULTS: Our network-based approaches indicated that ginsenoside Rg1 (GRg1) and saikosaponin d (Ssd) are the major constituents of KJG that …
FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim.
Sun T, Zhang J, Deng B, Fan X, Long T, Jin H, Tao S, Kang P, Tan Q. Sun T, et al. Acta Biochim Biophys Sin (Shanghai). 2020 Dec 29;52(12):1348-1359. doi: 10.1093/abbs/gmaa129. Acta Biochim Biophys Sin (Shanghai). 2020. PMID: 33167006 Free article.
Knockdown of FOXO1 and FOXO3a significantly decreased the cell sensitivity to cisplatin in vitro and in vivo. ...Mechanistically, LY294002 increased the expressions and nuclear accumulation of FOXO1 and FOXO3a. Knockdown of FOXO1 and FOXO3a abrogated the enha …
Knockdown of FOXO1 and FOXO3a significantly decreased the cell sensitivity to cisplatin in vitro and in vivo. ...Mechanistically, LY2 …
The PI3K/Akt1-FoxO1 Translocation Pathway Mediates EXf Effects on NIT-1 Cell Survival.
Hou GJ, Li CN, Huan Y, Liu SN, Liu Q, Liu MZ, Shen ZF. Hou GJ, et al. Exp Clin Endocrinol Diabetes. 2017 Nov;125(10):669-676. doi: 10.1055/s-0043-117048. Epub 2017 Sep 11. Exp Clin Endocrinol Diabetes. 2017. PMID: 28895639
Comparative transcription analysis showed up-regulation of igf-1r, irs-2, pI3k, akt1 and pdx-1 in NIT-1 cells after EXf treatment. Moreover, the up-regulation of PI3K and phosphorylation of Akt1 upon EXf treatment was confirmed by Western blot, both phenomena were a …
Comparative transcription analysis showed up-regulation of igf-1r, irs-2, pI3k, akt1 and pdx-1 in NIT-1 cells after EXf treatment. Mo …
An insight into PI3k/Akt pathway and associated protein-protein interactions in metabolic syndrome: A recent update.
Verma K, Jaiswal R, Paliwal S, Dwivedi J, Sharma S. Verma K, et al. J Cell Biochem. 2023 Jul;124(7):923-942. doi: 10.1002/jcb.30433. Epub 2023 Jul 6. J Cell Biochem. 2023. PMID: 37408526 Review.
Akt, a known serine/threonine-protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in three isoforms, Akt1, Akt2, and Akt3. Ubiquitously expressed Akt1 & Akt2 are essential for cell survival and are believed to …
Akt, a known serine/threonine-protein kinase B has been revealed to be an imperative protein of the PI3K/Akt pathway. Akt is available in th …
245 results